新生儿溶血病：经脐静脉穿刺进行胎儿血管内输血。

Rh disease: intravascular fetal blood transfusion by cordocentesis.

作者信息

Nicolaides K H, Soothill P W, Rodeck C H, Clewell W

机构信息

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

出版信息

Fetal Ther. 1986;1(4):185-92. doi: 10.1159/000262267.

DOI:10.1159/000262267

PMID:3136620

Abstract

A total of 130 cordocenteses, including 96 intravascular fetal blood transfusions, were performed in 21 pregnancies complicated by red cell isoimmunization. Transfusions were commended at 18-34 weeks' gestation and repeated up to 7 times, at 1- to 4-week intervals. The volumes of transfused blood were 5-150 ml, the haematocrits 62-88% and the rate of transfusions 1-15 ml/min. The pretransfusion fetal haematocrits were 5-34% and the posttransfusion ones 28-60%. Final transfusions were given at 32-36 weeks' gestation. Of the 21 pregnancies, 18 delivered at 31-39 weeks and 3 are continuing; 1 baby was stillborn and 17 are alive and well.

摘要

在21例并发红细胞同种免疫的妊娠中，共进行了130次脐带穿刺术，其中包括96次胎儿血管内输血。输血在妊娠18至34周进行，间隔1至4周重复进行，最多7次。输血量为5至150毫升，血细胞比容为62%至88%，输血速度为1至15毫升/分钟。输血前胎儿血细胞比容为5%至34%，输血后为28%至60%。最后一次输血在妊娠32至36周进行。21例妊娠中，18例在31至39周分娩，3例仍在继续妊娠；1例胎儿死产，17例存活且状况良好。