Clinical Hospital "Dubrava", Zagreb, Croatia.
Institute for Medical Research and Occupational Health, Zagreb, Croatia
Anticancer Res. 2019 Aug;39(8):4285-4289. doi: 10.21873/anticanres.13593.
BACKGROUND/AIM: Oral squamous cell carcinoma (OSCC) is a cancer with poor prognosis due to therapy resistance, locoregional recurrences, and distant metastases. There is on increased interest in profiling the androgen receptor (AR) in cancer biology. The aim of this study was to compare AR and Ki-67 levels in the neoplastic epithelium and stroma between non-metastatic and metastatic stages of OSCC.
Tissue specimens of 101 non-metastatic and 95 metastatic OSCC patients were analyzed by immunohistochemistry.
More than 20% of AR-positive cytoplasmic staining of OSCC epithelium was significantly associated with nuclear AR levels in the epithelium and increased AR levels in the stroma. In metastatic OSCC patients, Ki-67 was significantly higher than in non-metastatic OSCC patients.
More than 20% of AR-positive cytoplasmic staining in neoplastic OSSC epithelium is a significant predictor of OSCC progression risk.
背景/目的：口腔鳞状细胞癌（OSCC）是一种预后较差的癌症，其治疗耐药性、局部复发和远处转移率较高。人们越来越关注在癌症生物学中对雄激素受体（AR）进行分析。本研究旨在比较非转移性和转移性 OSCC 中肿瘤上皮和基质中 AR 和 Ki-67 水平。
对 101 例非转移性和 95 例转移性 OSCC 患者的组织标本进行免疫组织化学分析。
超过 20%的 OSCC 上皮细胞质中 AR 阳性染色与上皮核中 AR 水平和基质中 AR 水平升高显著相关。转移性 OSCC 患者的 Ki-67 水平明显高于非转移性 OSCC 患者。
超过 20%的肿瘤性 OSSC 上皮细胞质中 AR 阳性染色是 OSCC 进展风险的显著预测因子。
