Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Department of Surgical Pathology.
Cancer Biomark. 2018;22(4):747-753. doi: 10.3233/CBM-181302.
Discoidin domain receptors (DDRs), a collagen receptor tyrosine kinase, play a major role in cancer progression. DDR2 has been suggested as a prognostic marker in several cancer types; however, the correlation between DDR2 expression and clinical outcome of oral cancer patients in Taiwan population has not been investigated.
In the present study we sought to determine the clinical significance of Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) expression in oral squamous cell carcinoma (OSCC) patients. We examined DDR2 expression in OSCC specimens by immunohistochemistry and then we analyzed the association of DDR2 expression with clinicopathological factors in OSCC.
We divided 254 OSCC cases into two groups based on DDR2 expression levels and compared with several clinicopathological factors and their overall survival. The group with high DDR2 expression had significantly higher frequencies of lymph node metastasis (P= 0.0094) and AJCC stage (P= 0.0058) compared to the group with low DDR2 expression. Furthermore, the lymph node metastasis oral cancer patients with high DDR2 expression had low survival rate than low DDR2 group (P= 0.0458).
Our data indicate that DDR2 is a potent biomarker that can be used as an effective therapeutic target for treating OSCC patients with lymph node metastasis.
黏着斑激酶（DDRs）是一种胶原蛋白受体酪氨酸激酶，在癌症进展中起着重要作用。DDR2 已被认为是几种癌症类型的预后标志物；然而，在台湾人群中，DDR2 表达与口腔癌患者临床结局的相关性尚未得到研究。
在本研究中，我们试图确定 DDR2 表达在口腔鳞状细胞癌（OSCC）患者中的临床意义。我们通过免疫组织化学检查了 OSCC 标本中的 DDR2 表达，然后分析了 DDR2 表达与 OSCC 临床病理因素的相关性。
我们根据 DDR2 表达水平将 254 例 OSCC 病例分为两组，并比较了几组临床病理因素及其总生存率。与低 DDR2 表达组相比，高 DDR2 表达组的淋巴结转移（P=0.0094）和 AJCC 分期（P=0.0058）频率明显更高。此外，高 DDR2 表达的淋巴结转移口腔癌患者的生存率低于低 DDR2 组（P=0.0458）。
我们的数据表明，DDR2 是一种有效的生物标志物，可作为治疗淋巴结转移的 OSCC 患者的有效治疗靶点。
