Khwaja Raamis, Mantilla Emmanuel, Fink Karen, Pan Edward
UT Southwestern Medical Center, Dallas, TX, U.S.A.
Baylor University Medical Center, Dallas, TX, U.S.A.
Anticancer Res. 2019 Aug;39(8):4463-4465. doi: 10.21873/anticanres.13619.
This case report describes a patient with a rare occurrence of primary spinal intramedullary Ewing's sarcoma (ES) in the cervical and thoracic spine. The older age of disease occurrence, uncommon location in the cervical and thoracic spine, and EWSR1 gene fusion as the basis of diagnosis are unique features of this case. There is no clear protocol for treatment of primary extraskeletal ES of the spine, with controversy between evidence for pursuing surgery versus a combination of radiation and chemotherapy. Our patient was treated with temozolomide chemotherapy for recurrent metastatic disease of primary ES of the spine.
本病例报告描述了一名患者，其颈椎和胸椎罕见地发生了原发性脊髓内尤文肉瘤（ES）。发病年龄较大、在颈椎和胸椎的不常见位置以及作为诊断基础的EWSR1基因融合是该病例的独特特征。目前尚无明确的脊柱原发性骨外ES治疗方案，对于采取手术治疗还是放疗与化疗联合治疗存在争议。我们的患者接受了替莫唑胺化疗，用于治疗原发性脊柱ES的复发性转移性疾病。
