基质金属蛋白酶在胰腺导管内乳头状黏液性肿瘤中的表达

Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas.

作者信息

Akashi Masanori, Hisaka Toru, Sakai Hisamune, Ishikawa Hiroto, Kawahara Ryuichi, Goto Yuichi, Nomura Yoriko, Yasunaga Masafumi, Fujita Fumihiko, Tanigawa Masahiko, Naito Yoshiki, Akiba Jun, Yano Hirohisa, Tanaka Hiroyuki, Akagi Yoshito, Okuda Koji

机构信息

Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.

Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan

出版信息

Anticancer Res. 2019 Aug;39(8):4485-4490. doi: 10.21873/anticanres.13623.

DOI:10.21873/anticanres.13623

PMID:31366549

Abstract

BACKGROUND/AIM: Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions.

MATERIALS AND METHODS

The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining.

RESULTS

MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups.

CONCLUSION

MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.

摘要

背景/目的：导管内乳头状黏液性肿瘤（IPMN）具有多种组织学和形态学表现。基质金属蛋白酶（MMPs）被认为与肿瘤进展或预后不良有关。本研究的目的是阐明不同类型病变中IPMN变异的分子基础。