评估妇科癌症患者化疗引起的恶心呕吐及食物摄入量
Evaluating Chemotherapy-induced Nausea and Vomiting and Food Intake in Patients With Gynecologic Cancer.
作者信息
Komatsu Hiroaki, Oishi Tetsuro, Sato Shinya, Osaku Daiken, Sawada Mayumi, Kudoh Akiko, Nonaka Michiko, Sato Seiya, Shimada Muneaki, Itamochi Hiroaki, Harada Tasuku
机构信息
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.
Department of Obstetrics and Gynecology, Japanese Red Cross Yamaguchi Hospital, Yamaguchi, Japan.
出版信息
Anticancer Res. 2019 Aug;39(8):4555-4560. doi: 10.21873/anticanres.13633.
BACKGROUND/AIM: Treatments for controlling delayed nausea after chemotherapy are inadequate, potentially inciting malnutrition. We sought to determine the incidence of nausea, anorexia, and food intake after chemotherapy.
PATIENTS AND METHODS
Subjects were females with gynecological cancers who underwent chemotherapy between 2008 and 2013. Nausea, anorexia, and food intake in the acute (day 1) and delayed phases (days 2 and 3) were retrospectively evaluated.
RESULTS
Subjects included 156 females. Chemotherapies were highly (HEC; n=24) and moderately emetogenic (MEC; n=132). There were no significant between-group differences for anorexia control during either the acute or the delayed phase and both groups demonstrated significantly worse control of nausea during the delayed phase. In the HEC group, food intake was significantly reduced on days 2 and 3 compared with day 1.
CONCLUSION
Rates of nausea, anorexia, and food intake significantly worsened over time, particularly in the MEC group. Current supportive therapies appear inadequate and should be improved.
背景/目的：控制化疗后延迟性恶心的治疗方法并不充分，可能会引发营养不良。我们试图确定化疗后恶心、厌食和食物摄入量的发生率。
患者与方法
研究对象为2008年至2013年间接受化疗的妇科癌症女性患者。对急性（第1天）和延迟期（第2天和第3天）的恶心、厌食和食物摄入量进行回顾性评估。
结果
研究对象包括156名女性。化疗方案包括高致吐性化疗（HEC；n = 24）和中度致吐性化疗（MEC；n = 132）。急性或延迟期厌食控制方面两组间无显著差异，且两组在延迟期恶心控制均明显较差。在HEC组，与第1天相比，第2天和第3天食物摄入量显著减少。
结论
恶心、厌食和食物摄入量随时间显著恶化，尤其是在MEC组。目前的支持性治疗似乎不足，应予以改善。
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