子宫内膜癌无残留肿瘤患者复发的临床特征

Clinical Features of Recurrence in Patients Without Residual Tumour in Endometrial Cancer.

作者信息

Miyahara Daisuke, Yotsumoto Fusanori, Hirakawa Toyofumi, Yoshikawa Kenichi, Shigekawa Koichiro, Miyata Kohei, Ito Tomohiro, Nam Sung Ouk, Kurakazu Masamitsu, Kanamori Yasunobu, Amada Satoshi, Miyamoto Shingo

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Department of Obstetrics and Gynecology, Japanese Red Cross Yamaguchi Hospital, Yamaguchi, Japan.

出版信息

Anticancer Res. 2019 Aug;39(8):4581-4588. doi: 10.21873/anticanres.13637.

DOI:10.21873/anticanres.13637

PMID:31366563

Abstract

BACKGROUND/AIM: Initial treatment of endometrial cancer with surgery and platinum and taxane-based chemotherapy is often successful, but it remains unclear as to whether certain types of the disease relapse. The aim of this study was to identify the clinical features of recurrence in patients without residual tumour in endometrial cancer.

PATIENTS AND METHODS

Clinical features, histological type, and time to recurrence were analyzed in 640 endometrial cancer patients without residual tumours.

RESULTS

Of 640 patients, 517 were type I and 123 were type II. For type I, early recurrent (ER) disease and late recurrent (LR) disease were noted in 80 and 8 patients, respectively, and 97.5% of ER occurred within 2 years. After recurrence, 76.2% of ER and 50% of LR patients died. In type II, ER and LR were noted in 41 and 1 patients, respectively, and 97.6% of ER occurred within 2 years, of which 75.6% died after recurrence. One LR case died of disease.

CONCLUSION

Most patients recurred within 2 years irrespective of clinical stage or type.

摘要

背景/目的：子宫内膜癌的初始治疗采用手术以及基于铂类和紫杉烷的化疗通常是成功的，但尚不清楚某些类型的该疾病是否会复发。本研究的目的是确定子宫内膜癌无残留肿瘤患者复发的临床特征。

患者与方法

分析了640例无残留肿瘤的子宫内膜癌患者的临床特征、组织学类型和复发时间。

结果

640例患者中，517例为I型，123例为II型。对于I型，分别有80例和8例出现早期复发（ER）疾病和晚期复发（LR）疾病，97.5%的ER发生在2年内。复发后，76.2%的ER患者和50%的LR患者死亡。在II型中，分别有41例和1例出现ER和LR，97.6%的ER发生在2年内，其中75.6%在复发后死亡。1例LR患者死于该疾病。