Vikram Selvi Radhika, Robinson Jonathan, Thanawala Tina, Franklin John, Boeckstaens Shari, Hall Marcia, Sanusi Fatai Adegboyega, Padwick Malcolm, Stanciu Paul
Women and Children's Services, West Hertfordshire Hospitals NHS Trust, St Albans, UK.
School of Health, Teesside University, Middlesbrough, UK.
Cochrane Database Syst Rev. 2024 Jun 20;6(6):CD014568. doi: 10.1002/14651858.CD014568.
This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To assess the diagnostic accuracy of endometrial sampling with histology in the diagnosis of endometrial cancer in women with postmenopausal bleeding and thickened endometrium on ultrasound. Diagnosis will be verified by the reference standards, hysteroscopy with histology, obtained by targeted (such as grasp biopsy of the endometrium or resection of focal pathology) or global sampling (with dilation and curettage), and histology of hysterectomy specimens. Secondary objectives To determine the diagnostic accuracy of different sampling devices and methods in the detection of endometrial cancer To assess the diagnostic accuracy of endometrial sampling devices and methods to detect endometrial hyperplasia To determine accuracy in diagnosing endometrial cancer and endometrial hyperplasia at different endometrial thicknesses of 3 mm, 4 mm and 5 mm To investigate sources of heterogeneity.
这是一项Cochrane系统评价（诊断性）的方案。目标如下：评估在超声检查显示绝经后出血且子宫内膜增厚的女性中，子宫内膜组织学取样对子宫内膜癌的诊断准确性。诊断将通过参考标准进行验证，即通过靶向（如子宫内膜抓活检或局灶性病变切除）或全面取样（刮宫）获得的宫腔镜检查及组织学检查，以及子宫切除标本的组织学检查。次要目标：确定不同取样设备和方法在检测子宫内膜癌方面的诊断准确性；评估子宫内膜取样设备和方法检测子宫内膜增生的诊断准确性；确定在子宫内膜厚度为3毫米、4毫米和5毫米时诊断子宫内膜癌和子宫内膜增生的准确性；调查异质性来源。
