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血小板浓缩物中生长因子的比较评估：一项研究。

Comparative evaluation of growth factors from platelet concentrates: An study.

作者信息

Chatterjee Anirban, Debnath Koel

机构信息

Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India.

出版信息

J Indian Soc Periodontol. 2019 Jul-Aug;23(4):322-328. doi: 10.4103/jisp.jisp_678_18.

DOI:10.4103/jisp.jisp_678_18
PMID:31367128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6628779/
Abstract

AIM

The aim of the study was to compare and evaluate the various growth factors released for a period of 23 days from platelet rich fibrin (PRF) and platelet rich fibrin matrix (PRFM).

MATERIALS AND METHODS

A total of 15 systemically healthy controls were recruited and 10 ml of blood sample was withdrawn from the individual. Following the standard centrifugation protocol, PRF and PRFM were prepared. The platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor (TGF), and insulin growth factor (IGF) were evaluated for 23 days.

RESULTS

The PDGF released from PRFM was statistically significant from PRF till the 15 day of release. The VEGF too had an increased release up till the 15 day from PRFM group as compared to PRF, but no statistically significant difference could be obtained. EGF from the 15 day to 23 day had a greater release from PRFM group as compared to PRF group. FGF from 7 day to 23 day had statistically significant difference in the PRFM group as compared to PRF group. TGF and IGF had statistically significant difference in PRFM group as compared to PRF group from 11 day to 23 day and 1 to 17 day, respectively.

CONCLUSION

The initial and robust release of GFs was seen in PRFM group at earlier days, whereas a steady and constant release of six GFs could be appreciated from PRF group upto 23 day. Therefore, for a rapid and early healing and regeneration, both the platelet concentrates can be utilized in periodontal therapy.

摘要

目的

本研究的目的是比较和评估富含血小板纤维蛋白（PRF）和富含血小板纤维蛋白基质（PRFM）在23天内释放的各种生长因子。

材料与方法

共招募15名全身健康的对照者，从每个人身上抽取10ml血液样本。按照标准离心方案制备PRF和PRFM。对血小板衍生生长因子（PDGF）、血管内皮生长因子（VEGF）、表皮生长因子（EGF）、成纤维细胞生长因子（FGF）、转化生长因子（TGF）和胰岛素生长因子（IGF）进行23天的评估。

结果

从PRFM释放的PDGF直到释放第15天与PRF相比具有统计学意义。与PRF相比，PRFM组的VEGF在第15天之前也有增加的释放，但未获得统计学显著差异。与PRF组相比，PRFM组从第15天到23天的EGF释放量更大。与PRF组相比，PRFM组从第7天到23天的FGF有统计学显著差异。与PRF组相比，PRFM组的TGF和IGF分别在第11天到23天和第1天到17天有统计学显著差异。

结论

在早期，PRFM组可见生长因子的初始和强劲释放，而PRF组在23天内可观察到六种生长因子的稳定持续释放。因此，为了快速早期愈合和再生，两种血小板浓缩物均可用于牙周治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/39b843b4b742/JISP-23-322-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/473c0a897296/JISP-23-322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/67d8500473d2/JISP-23-322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/cebcaf0addee/JISP-23-322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/9827b0991a4d/JISP-23-322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/baee20d68335/JISP-23-322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/8daabd5eb5a9/JISP-23-322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/26aa61dc41ae/JISP-23-322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/7dcb874a4619/JISP-23-322-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/39b843b4b742/JISP-23-322-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/473c0a897296/JISP-23-322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/67d8500473d2/JISP-23-322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/cebcaf0addee/JISP-23-322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/9827b0991a4d/JISP-23-322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/baee20d68335/JISP-23-322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/8daabd5eb5a9/JISP-23-322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/26aa61dc41ae/JISP-23-322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/7dcb874a4619/JISP-23-322-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f6f/6628779/39b843b4b742/JISP-23-322-g009.jpg

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