Suppr超能文献

精准医学时代的多样性——从实验室到临床实践的转化。

Diversity in the Era of Precision Medicine - From Bench to Bedside Implementation.

机构信息

School of Public Health, University of North Texas (UNT) System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX.

Graduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX.

出版信息

Ethn Dis. 2019 Jul 18;29(3):517-524. doi: 10.18865/ed.29.3.517. eCollection 2019 Summer.

Abstract

Recent evidence shows how patients' unique genetic makeup can affect disease outcomes and the increasing availability of targeted treatments promises a future in health care, whereby treatments will be tailored to individual needs. This article reports on the topics discussed at the 13th Annual Texas Conference on Health Disparities, organized by the Texas Center for Health Disparities at the University of North Texas Health Science Center; the meeting focused on the theme, "Diversity in the Era of Precision Medicine" and was held during June 2018 in Fort Worth, Texas. The primary focus of this conference, which brought together clinical and basic scientists, was on the inclusion of diversity in precision medicine to bridge the gap in health disparities. Here, we present the highlights of the conference that include the potential application of precision medicine at the population level, the effects of precision medicine and direct-to-consumer testing on health disparities, genetic basis of health disparities, pharmacogenomics, and strategies to enhance participation of under-represented populations in precision medicine. Furthermore, we conclude with recommendations for future implementation, including how to mitigate disparities in genomics services and enhance participation of diverse groups in clinical trials.

摘要

最近的证据表明,患者独特的基因构成如何影响疾病的结果,而靶向治疗的日益普及有望为医疗保健带来未来,即治疗将根据个体需求进行定制。本文报道了在第 13 届德克萨斯州健康差异年度会议上讨论的主题,该会议由北德克萨斯健康科学中心的德克萨斯州健康差异中心组织;会议的主题是“精准医学时代的多样性”,于 2018 年 6 月在德克萨斯州沃思堡举行。这次会议的主要重点是将多样性纳入精准医学,以弥合健康差异的差距。在这里,我们介绍了会议的重点,包括精准医学在人群层面的潜在应用、精准医学和直接面向消费者的测试对健康差异的影响、健康差异的遗传基础、药物基因组学以及增强代表性不足人群参与精准医学的策略。此外,我们还对未来的实施提出了建议,包括如何减轻基因组服务中的差异,并增强不同群体参与临床试验的程度。

相似文献

2
Role of genomics in eliminating health disparities.基因组学在消除健康差距方面的作用。
J Carcinog. 2015 Sep 11;14:6. doi: 10.4103/1477-3163.165158. eCollection 2015.
3
Is precision medicine the future of healthcare?精准医疗是医疗保健的未来吗?
Per Med. 2017 Nov;14(6):459-461. doi: 10.2217/pme-2017-0060. Epub 2017 Nov 24.

引用本文的文献

1
8
Factors influencing precision medicine knowledge and attitudes.影响精准医学知识和态度的因素。
PLoS One. 2020 Nov 11;15(11):e0234833. doi: 10.1371/journal.pone.0234833. eCollection 2020.
10
Precision Medicine Approaches to Health Disparities Research.健康差异研究的精准医学方法。
Ethn Dis. 2020 Apr 2;30(Suppl 1):129-134. doi: 10.18865/ed.30.S1.129. eCollection 2020.

本文引用的文献

7
Prioritizing diversity in human genomics research.优先考虑人类基因组学研究中的多样性。
Nat Rev Genet. 2018 Mar;19(3):175-185. doi: 10.1038/nrg.2017.89. Epub 2017 Nov 20.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验