School of Public Health, University of North Texas (UNT) System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX.
Graduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX.
Ethn Dis. 2019 Jul 18;29(3):517-524. doi: 10.18865/ed.29.3.517. eCollection 2019 Summer.
Recent evidence shows how patients' unique genetic makeup can affect disease outcomes and the increasing availability of targeted treatments promises a future in health care, whereby treatments will be tailored to individual needs. This article reports on the topics discussed at the 13th Annual Texas Conference on Health Disparities, organized by the Texas Center for Health Disparities at the University of North Texas Health Science Center; the meeting focused on the theme, "Diversity in the Era of Precision Medicine" and was held during June 2018 in Fort Worth, Texas. The primary focus of this conference, which brought together clinical and basic scientists, was on the inclusion of diversity in precision medicine to bridge the gap in health disparities. Here, we present the highlights of the conference that include the potential application of precision medicine at the population level, the effects of precision medicine and direct-to-consumer testing on health disparities, genetic basis of health disparities, pharmacogenomics, and strategies to enhance participation of under-represented populations in precision medicine. Furthermore, we conclude with recommendations for future implementation, including how to mitigate disparities in genomics services and enhance participation of diverse groups in clinical trials.
最近的证据表明，患者独特的基因构成如何影响疾病的结果，而靶向治疗的日益普及有望为医疗保健带来未来，即治疗将根据个体需求进行定制。本文报道了在第 13 届德克萨斯州健康差异年度会议上讨论的主题，该会议由北德克萨斯健康科学中心的德克萨斯州健康差异中心组织；会议的主题是“精准医学时代的多样性”，于 2018 年 6 月在德克萨斯州沃思堡举行。这次会议的主要重点是将多样性纳入精准医学，以弥合健康差异的差距。在这里，我们介绍了会议的重点，包括精准医学在人群层面的潜在应用、精准医学和直接面向消费者的测试对健康差异的影响、健康差异的遗传基础、药物基因组学以及增强代表性不足人群参与精准医学的策略。此外，我们还对未来的实施提出了建议，包括如何减轻基因组服务中的差异，并增强不同群体参与临床试验的程度。
