Henze Larissa, Sckell Axel, März Alexander, Junghanß Christian
Zentrum für Innere Medizin, Medizinische Klinik III, Klinik für Hämatologie, Onkologie, Palliativmedizin, Universitätsmedizin Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Deutschland.
Abteilung für Unfall‑, Hand- und Wiederherstellungschirurgie, Chirurgische Klinik und Poliklinik, Universitätsmedizin Rostock, 18057, Rostock, Deutschland.
Unfallchirurg. 2019 Aug;122(8):633-645. doi: 10.1007/s00113-019-0693-x.
As the population gets older the prevalence of atrial fibrillation and venous thromboembolism also increases. Therefore, more patients require anticoagulation and currently direct oral anticoagulants (DOAC), such as dabigatran etexilate, apixaban, rivaroxaban and edoxaban are preferred to vitamin K antagonists (VKA), mainly because of the more favorable risk-benefit profile with respect to bleeding. Older patients in particular frequently present at the accident and emergency department due to falls and an increased risk of fractures. The perioperative management of these patients who are treated with DOACs is a challenge in the clinical routine and needs special consideration. This article discusses these issues in an interdisciplinary approach and develops strategies for the perioperative management of patients treated with DOACs and undergoing trauma or orthopedic surgery.
随着人口老龄化,房颤和静脉血栓栓塞的患病率也在增加。因此,更多患者需要抗凝治疗,目前直接口服抗凝剂(DOAC),如达比加群酯、阿哌沙班、利伐沙班和依度沙班,比维生素K拮抗剂(VKA)更受青睐,主要是因为在出血方面具有更有利的风险效益比。特别是老年患者,由于跌倒和骨折风险增加,经常出现在急诊科。这些接受DOAC治疗的患者的围手术期管理是临床常规中的一项挑战,需要特别考虑。本文采用跨学科方法讨论这些问题,并制定接受DOAC治疗且正在接受创伤或骨科手术患者的围手术期管理策略。