Department of Surgery, Oncology, and Stomatology, University of Palermo, Palermo, Italy -
Department of Surgery, Oncology, and Stomatology, University of Palermo, Palermo, Italy.
Minerva Med. 2019 Oct;110(5):455-463. doi: 10.23736/S0026-4806.19.06068-3.
Peripheral neuropathies are frequently encountered in clinical practice and are associated with a major impairment in quality of life. However, their management remains poor, and current therapies are often burdened with major side effects and can present poor efficacy on pain and functionality. Therefore, it has been suggested that the combination of two or more different drugs may improve analgesic efficacy and reduce side effects. Tricortin® 1000 is formulated with 12 mg of Brain cortex phospholipid liposomes + 1000 µg of Cyanocobalamin injectable solution (PL+CNCbl) for intramuscular use and is indicated in the treatment of poly-algo-neuropathic syndromes. This combination exerts a marked neurotrophic action by promoting the synthesis of endogenous phospholipids; moreover, the peculiar formulation optimizes the delivery of CNCbl which has analgesic and neurotrophic action. This paper discusses the pharmacotherapy of peripheral neuropathies, including low-back pain, neck pain, postherpetic neuropathy (PHN) and focuses on the fixed dose combination PL+CNCbl clinical efficacy in association with other treatments or in monotherapy.
周围神经病在临床实践中经常遇到，与生活质量的严重受损有关。然而，它们的治疗仍然很差，目前的治疗方法往往伴随着严重的副作用，并且在疼痛和功能方面效果不佳。因此，有人建议将两种或两种以上的不同药物联合使用可能会提高镇痛效果并减少副作用。Tricortin® 1000 含有 12 毫克脑皮质磷脂脂质体+1000 微克氰钴胺注射溶液（PL+CNCbl），用于肌肉注射，适用于治疗多发性神经病理性综合征。该组合通过促进内源性磷脂的合成发挥明显的神经营养作用；此外，特殊配方优化了具有镇痛和神经营养作用的 CNCbl 的传递。本文讨论了周围神经病的药物治疗，包括腰痛、颈痛、带状疱疹后神经痛（PHN），并重点介绍了 PL+CNCbl 固定剂量联合治疗与其他治疗或单一疗法相关的临床疗效。
