通过钯催化的C-H键活化从简单丙烯酰胺合成异噻唑啉酮
Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C-H Bond Activation.
作者信息
Chen Mu-Yi, Pannecoucke Xavier, Jubault Philippe, Besset Tatiana
机构信息
Normandie Univ, INSA Rouen, UNIROUEN, CNRS , COBRA (UMR 6014) , 76000 Rouen , France.
出版信息
J Org Chem. 2019 Oct 18;84(20):13194-13202. doi: 10.1021/acs.joc.9b01872. Epub 2019 Aug 19.
PMID:31368309
Abstract
A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C-H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).
摘要
开发了一种新方法，通过过渡金属催化的C-H键官能化从简单的丙烯酰胺制备异噻唑啉酮衍生物。这种使用亲电硫氰酸盐源的钯催化反应为制备一系列官能化异噻唑啉酮衍生物提供了一种有效工具（21个实例，产率高达71%）。
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