Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Rouen 76000, France.
ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd University, Faculty of Science, Budapest H-1117, Hungary.
Chem Commun (Camb). 2021 Jun 24;57(51):6241-6244. doi: 10.1039/d1cc02007b.
A straightforward 2,2,2-trifluoroethylation of acrylamides by Pd-catalyzed C-H bond activation was reported by using a fluorinated hypervalent iodine reagent as a coupling partner. At room temperature, this additive-free approach allowed the synthesis of Z-2,2,2-trifluoroethylated acrylamides (19 examples, up to 73% yield) in a stereoselective manner. Under these mild reaction conditions, the methodology turned out to be functional group tolerant and mechanistic studies gave us a better understanding of the transformation.
报道了一种通过 Pd 催化的 C-H 键活化实现丙烯酰胺的直接 2,2,2-三氟乙基化反应，使用氟化高价碘试剂作为偶联伙伴。在室温下，这种无添加剂的方法以立体选择性的方式允许合成 Z-2,2,2-三氟乙基化丙烯酰胺（19 个实例，最高收率达 73%）。在这些温和的反应条件下，该方法对官能团具有耐受性，并且通过机理研究使我们对转化有了更好的理解。
