Ling Wei, Hao Yafeng, Wang Hanjie, Xu Hang, Huang Xian
Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China.
Nanotechnology. 2019 Oct 18;30(42):424002. doi: 10.1088/1361-6528/ab30b6. Epub 2019 Aug 1.
We present a novel Cu-metal-organic framework (MOF) with two-dimensional layered topology and techniques to integrate it with flexible sensors for electrochemical detection. The unique Cu-MOF is formed by coordinating Cu ions with carboxylic oxygen groups, resulting in layered structures interlayerly connected by hydrogen bonds. The resulting flexible sensors exhibit capability in detecting ascorbic acid (AA), hydrogen peroxide (HO) and L-Histidine (L-His) with detection limits of 2.94, 4.1 and 5.3 μM, respectively. The linear ranges of the sensors compare favorably with other sensors based on rigid platforms that offer similar sensitivity. According to the result of cytotoxicity study, the MOFs-modified flexible sensors exhibit good biocompatibility to cells, suggesting potential use in in vivo chemical detection. The results presented here demonstrate applications of MOFs in facilitating highly stable electrochemical detection in flexible electronics, and provide fundamental knowledge about structure-dependent electrochemical properties of MOFs and changing behaviors of flexible MOFs membranes under external strain. More MOFs-based flexible sensors may be developed to explore different properties of MOFs by varying their compositions and structures for healthcare and clinic applications.
我们展示了一种具有二维层状拓扑结构的新型铜基金属有机框架（MOF）以及将其与用于电化学检测的柔性传感器集成的技术。这种独特的铜基金属有机框架是通过铜离子与羧基氧原子配位形成的，从而产生由氢键层间连接的层状结构。由此产生的柔性传感器具有检测抗坏血酸（AA）、过氧化氢（HO）和L-组氨酸（L-His）的能力，检测限分别为2.94、4.1和5.3 μM。该传感器的线性范围与基于刚性平台且具有相似灵敏度的其他传感器相比具有优势。根据细胞毒性研究结果，MOF修饰的柔性传感器对细胞表现出良好的生物相容性，表明其在体内化学检测中的潜在用途。此处展示的结果证明了MOF在促进柔性电子器件中高度稳定的电化学检测方面的应用，并提供了关于MOF的结构依赖性电化学性质以及柔性MOF膜在外部应变下的变化行为的基础知识。通过改变其组成和结构，可能会开发出更多基于MOF的柔性传感器，以探索MOF在医疗保健和临床应用中的不同特性。
