Escurat M, Gumpel M, Lachapelle F, Gros F, Portier M M
Collège de France, Laboratoire de Biochimie cellulaire, Paris.
C R Acad Sci III. 1988;306(14):447-56.
Peripherin, an intermediate filament protein, was originally detected by biochemical methods in the neurons of the peripheral nervous system. We now studied its expression and cellular localization by immunocytochemical methods in the developing rat embryo, and compared them with the expression and localization of the 68 kDa neurofilament protein. It appears that peripherin is expressed not only in the neurons of the peripheral nervous system, but also in some well defined neuronal populations of the central nervous system. These results focus on the questions of the phylogenetic origin and of the function of peripherin.
外周蛋白是一种中间丝蛋白，最初是通过生化方法在外周神经系统的神经元中检测到的。我们现在通过免疫细胞化学方法研究了其在发育中的大鼠胚胎中的表达和细胞定位，并将其与68 kDa神经丝蛋白的表达和定位进行了比较。外周蛋白似乎不仅在外周神经系统的神经元中表达，而且在中枢神经系统的一些明确的神经元群体中也有表达。这些结果聚焦于外周蛋白的系统发生起源和功能问题。
