Basic mechanisms of lymphocyte recirculation in Lewis rats.

Lymphocyte locomotion in vivo depends upon an intact network of subplasmalemmal contractile microfilaments which are linked through the membrane to surface receptors, and the distribution and stabilization of recognition receptors may be controlled by microtubules and/or 10-nm filaments in the cytoplasm. The differential effects of cytochalasin-A and colchicine on lymphocyte homing and locomotion have proven useful in dissecting the subcellular events underlying the process of lymphocyte recirculation.