Department of Clinical Pharmacology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Pharmacogenomics. 2019 Jul;20(11):829-845. doi: 10.2217/pgs-2019-0031. Epub 2019 Aug 1.
Antidepressant response could be from 42 to 50% genetically determined. Venlafaxine (VEN) was the sixth most-prescribed antidepressant in the USA in 2017. Therefore, we reviewed studies which focused on the pharmacogenetics of VEN and found that there is a lack of guidelines for pharmacogenetic testing for VEN. Within investigated genetic polymorphisms, few of them can be indicated as potential predictors of VEN efficacy and tolerance. However, additional pharmacogenetic studies of VEN should be performed to reproduce already obtained results or explain contradictory ones. The individualization of pharmacotherapy is a key issue in providing patients with the highest possible quality of treatment, therefore pharmacogenetic studies should be one of the components of therapy optimization.
抗抑郁反应可能有 42%到 50%是由基因决定的。文拉法辛（VEN）是 2017 年美国第六大处方抗抑郁药。因此，我们回顾了专注于 VEN 药物遗传学的研究，发现目前缺乏 VEN 药物遗传学检测的指南。在所研究的遗传多态性中，只有少数可以作为 VEN 疗效和耐受性的潜在预测因子。然而，应该开展更多 VEN 的药物遗传学研究，以重现已获得的结果或解释相互矛盾的结果。药物治疗的个体化是为患者提供尽可能高质量治疗的关键问题，因此药物遗传学研究应该是治疗优化的组成部分之一。
