Steiner M, Links P S, Korzekwa M
Faculty of Health Sciences, McMaster University, Hamilton, Ontario.
Can J Psychiatry. 1988 Jun;33(5):350-4. doi: 10.1177/070674378803300507.
The state of knowledge in the area of suggested biological markers that may delineate subpopulations of patients with borderline personality disorders (BPD) is reviewed. There is widespread disagreement as to the specificity of these markers. The clinical implications of Axis I--Axis II, state vs. trait, acute vs. chronic, and definite vs. probable diagnoses, all seem to contribute to the confusion in this area. Some patients with BPD and with schizotypal personality disorders (SPD) share neuroendocrine abnormalities with affective disorders (AD) and schizophrenic (SCH) patients respectively. This interface and/or potential overlap between personality disorders (PD) and the major mental disorders is discussed with special reference to the DST, TRH/TSH test, and REM latency which have already been established as valuable biological markers for certain subtypes of depression. In contrast, biologic abnormalities observed in chronic schizophrenia are also present in some SPD patients. Current data are supportive of the hypothesis that some PD patients are independent whereas others are genetically related to the major mental disorders.
本文综述了可能用于界定边缘型人格障碍（BPD）患者亚群的生物标志物领域的知识现状。对于这些标志物的特异性存在广泛的分歧。轴I-轴II、状态与特质、急性与慢性以及明确与可能诊断的临床意义，似乎都导致了该领域的混乱。一些BPD患者和分裂型人格障碍（SPD）患者分别与情感障碍（AD）和精神分裂症（SCH）患者存在神经内分泌异常。本文特别参考了已被确立为某些抑郁症亚型有价值生物标志物的地塞米松抑制试验（DST）、促甲状腺激素释放激素/促甲状腺激素试验（TRH/TSH）和快速眼动睡眠潜伏期，讨论了人格障碍（PD）与主要精神障碍之间的这种关联和/或潜在重叠。相反，在慢性精神分裂症中观察到的生物学异常也存在于一些SPD患者中。目前的数据支持这样一种假设，即一些PD患者是独立的，而另一些则与主要精神障碍存在遗传关联。
