Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen) , Sun Yat-sen University , Guangzhou 510275 , China.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , 637371 Singapore.
ACS Nano. 2019 Aug 27;13(8):8537-8565. doi: 10.1021/acsnano.9b04436. Epub 2019 Aug 5.
As a mussel-inspired material, polydopamine (PDA), possesses many properties, such as a simple preparation process, good biocompatibility, strong adhesive property, easy functionalization, outstanding photothermal conversion efficiency, and strong quenching effect. PDA has attracted increasingly considerable attention because it provides a simple and versatile approach to functionalize material surfaces for obtaining a variety of multifunctional nanomaterials. In this review, recent significant research developments of PDA including its synthesis and polymerization mechanism, physicochemical properties, different nano/microstructures, and diverse applications are summarized and discussed. For the sections of its applications in surface modification and biomedicine, we mainly highlight the achievements in the past few years (2016-2019). The remaining challenges and future perspectives of PDA-based nanoplatforms are discussed rationally at the end. This timely and overall review should be desirable for a wide range of scientists and facilitate further development of surface coating methods and the production of PDA-based materials.
受贻贝启发的材料聚多巴胺（PDA）具有许多特性，例如制备工艺简单、良好的生物相容性、较强的粘附性、易于功能化、出色的光热转换效率和强烈的猝灭效应。PDA 因其为功能化材料表面提供了一种简单而通用的方法，从而获得了各种多功能纳米材料，因此受到了越来越多的关注。在这篇综述中，总结和讨论了 PDA 的最新重要研究进展，包括其合成和聚合机制、物理化学性质、不同的纳米/微观结构以及各种应用。在其在表面改性和生物医学中的应用部分，我们主要强调了过去几年（2016-2019 年）的成就。最后，合理地讨论了基于 PDA 的纳米平台的剩余挑战和未来展望。这篇及时而全面的综述应该会受到广大科学家的欢迎，并有助于进一步发展表面涂覆方法和 PDA 基材料的生产。
