Faculty of Science, Engineering and Technology, Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia.
Biotechnol J. 2019 Dec;14(12):e1900080. doi: 10.1002/biot.201900080. Epub 2019 Aug 8.
Since the first time mussel-inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA-based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.
自首次发现贻贝类聚合物聚多巴胺 (PDA) 以来，由于其独特的性质，如表面化学、生物相容性、能够附着在任何表面以及出色的光热转换性能，它引起了众多科学家的极大关注，特别是那些从事药物输送以及细菌和肿瘤治疗领域的科学家。近年来，人们广泛研究了将 PDA 用于各种类型结构的治疗用途。考虑到该领域的快速发展，本综述旨在涵盖并突出介绍（截至 2016 年至今）用于治疗用途的基于 PDA 的材料的最新成果。本文描述了 PDA 的不同结构及其形成策略，包括胶体颗粒、中空结构和涂层薄膜。此外，本综述的重点是这些 PDA 纳米结构的治疗应用。
