Hierarchical modulation of auditory prediction error signaling is independent of attention.

The auditory system is tuned to detect rhythmic regularities in the environment which can occur on different timescales. Event-related potentials such as mismatch negativity (MMN) and P3b are thought to index local and global deviance, respectively. However, it is not clear how these hierarchical levels interact and to what extent attention modulates this interaction. In this EEG study with 17 healthy young adults, we used a hierarchical oddball paradigm with local (sequence-level) and global (block-level) violations in attended and unattended conditions. Amplitude of N2 and P3b were analyzed in a 222 factorial model (local status, global status, attention condition). We found a significant interaction between the local and global status on the N2 amplitude, while there was no significant three-way interaction with attention, together demonstrating that lower-level prediction error is modulated by detection of higher-order regularity but expressed independently of attention. By contrast, higher-level prediction error, indexed by P3b, was sensitive to global regularity violations if the auditory stream was attended. The results demonstrate the capacity of our auditory perception to preattentively resolve conflicts between different levels of predictive hierarchy even across longer time intervals as indexed by MMN modulation, while P3b represents a different, attention-dependent system.