使用脱水人羊膜与羊膜/绒毛膜同种异体移植治疗面部浅度烧伤。

The Use of Dehydrated Human Amniotic Membrane Versus Amniotic/Chorionic Membrane Allografts to Treat Partial Thickness Facial Burns.

作者信息

Puyana Salomon, Ruiz Samuel, Elkbuli Adel, Bernal Eileen, McKenney Mark, Askari Morad, Lim Rizal, Mir Haaris

机构信息

Department of Surgery, Kendall Regional Medical Center.

Department of Surgery, University of South Florida, Tampa, FL.

出版信息

J Craniofac Surg. 2020 Jan/Feb;31(1):201-203. doi: 10.1097/SCS.0000000000005834.

DOI:10.1097/SCS.0000000000005834

PMID:31369508

Abstract

BACKGROUND

Facial burns have significant physical and psychologic effects on patients. Human dehydrated amniotic membrane represents novel technology, yet its outcome has not been sufficiently studied to guide practice. The objective of our study is to compare the benefits of amniotic membrane (DHAM) to amniotic/chorionic membrane (DHACM) skin substitutes to treat partial thickness facial burns.

METHODS

Retrospective review of data collected from our institutional burn registry from 2012 to 2016. Demographic characteristics including age, total body surface area (TBSA) burn and injury severity scores were collected and outcome measures were compared between the 2 groups. Paired sample t-test and Chi-squared were used with significance defined as P < 0.05.

RESULTS

A total of 77 adult patients with partial thickness facial burns who received DHAM and DHACM skin substitutes were included in the analysis. The mean age for the DHAM group was 39.8 compared to 41.4 for the DHACM. Mean TBSA was similar, with 10.9% in the DHAM group compared to 8.3% in the DHACM. Patients receiving DHAM had higher requirement for skin substitute surgical reapplications as compared to the DHACM group (23.7% versus 5.1%, P ≤ 0.05). Remaining morbidities remained low and not significantly different between patients receiving DHAM and DHACM substitutes (P > 0.05).

CONCLUSION

The DHAM and DHACM skin substitutes are valid and safe alternatives in the treatment of adult partial thickness facial burns.

摘要

背景

面部烧伤对患者有显著的生理和心理影响。人脱水羊膜代表了一种新技术，但其治疗效果尚未得到充分研究以指导临床实践。我们研究的目的是比较羊膜（DHAM）与羊膜/绒毛膜（DHACM）皮肤替代物治疗面部浅Ⅱ度烧伤的效果。

方法

回顾性分析2012年至2016年从我们机构烧伤登记处收集的数据。收集包括年龄、烧伤总面积（TBSA）和损伤严重程度评分等人口统计学特征，并比较两组的治疗效果指标。采用配对样本t检验和卡方检验，显著性定义为P<0.05。

结果

共有77例接受DHAM和DHACM皮肤替代物治疗的成年面部浅Ⅱ度烧伤患者纳入分析。DHAM组的平均年龄为39.8岁，而DHACM组为41.4岁。平均TBSA相似，DHAM组为10.9%，DHACM组为8.3%。与DHACM组相比，接受DHAM治疗的患者对皮肤替代物手术再应用的需求更高（23.7%对5.1%，P≤0.05）。其余发病率仍然较低，接受DHAM和DHACM替代物治疗的患者之间无显著差异（P>0.05）。