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解开人类长寿的遗传学之谜——一项具有挑战性的探索。

Untangling the Genetics of Human Longevity-A Challenging Quest.

机构信息

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.

The Danish Twin Registry and Epidemiology, Biodemography and Biostatistics, Department of Public Health, University of Southern Denmark, 5000 Odense-C, Denmark.

出版信息

Genes (Basel). 2019 Jul 31;10(8):585. doi: 10.3390/genes10080585.

DOI:10.3390/genes10080585
PMID:31370355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6722970/
Abstract

Human average life expectancy in developed countries has increased dramatically in the last century, a phenomenon which is potentially accompanied by a significant rise in multi-morbidity and frailty among older individuals.[...].

摘要

在过去的一个世纪里,发达国家的人类平均预期寿命显著增加,这一现象可能伴随着老年人的多病共存和虚弱程度的显著上升。[...]。

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本文引用的文献

1
Longevity: Lesson from Model Organisms.长寿:模式生物的启示。
Genes (Basel). 2019 Jul 9;10(7):518. doi: 10.3390/genes10070518.
2
Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.异生物质代谢酶的个体间变异性:对人类衰老和长寿的影响。
Genes (Basel). 2019 May 27;10(5):403. doi: 10.3390/genes10050403.
3
Exceptional Longevity and Polygenic Risk for Cardiovascular Health.非凡的长寿和心血管健康的多基因风险。
Genes (Basel). 2019 Mar 18;10(3):227. doi: 10.3390/genes10030227.
4
The Genetic Variability of in Different Human Populations and Its Implications for Longevity.不同人群中 基因变异与长寿的关系
Genes (Basel). 2019 Mar 15;10(3):222. doi: 10.3390/genes10030222.
5
Lifespans of Twins: Does Zygosity Matter?双胞胎的寿命:同卵双生是否重要?
Genes (Basel). 2019 Feb 20;10(2):166. doi: 10.3390/genes10020166.
6
Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.肌醇多磷酸激酶 (),一种编码潜在多功能蛋白的基因,有助于人类女性长寿。
Genes (Basel). 2019 Feb 8;10(2):125. doi: 10.3390/genes10020125.
7
Analysis of the Association Between and Genetic Variation and Leukocyte Telomere Length and Human Lifespan-A Follow-Up Study.分析 与 基因变异与白细胞端粒长度和人类寿命的关系:一项随访研究。
Genes (Basel). 2019 Jan 25;10(2):82. doi: 10.3390/genes10020082.