Department of Optics and Photonics, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Int J Environ Res Public Health. 2019 Jul 31;16(15):2742. doi: 10.3390/ijerph16152742.
The paper presents, for the first time, corneal buckling, during the air puff applanation, recorded with use of Ocular Response Analyzer (ORA), when the cornea is deeper deformed after its applanation. Precise numerical analysis of the air pressure curve from the raw data, distinct local disturbances of the curve, which appear almost exactly at the time of the first and the second applanations. Thirty measurements taken on six eyes show clear dependencies between times of both applanations and appearances of local wave disturbances on the air pressure curve as well as between the amplitude of pressure wave disturbances and the respective height of applanation curve. These findings can be interpreted as a result of very fast corneal buckling, that produces the air pressure wave, propagating from the cornea towards the device. The quantitative dependencies measured and described in this study, enable to characterize the individual buckling during respective applanations. Due to these individual characterizations and dependencies it is possible to understand and describe better the ultrafast corneal applanation process. Such phenomena could likely be employed to increase the accuracy of measured parameters by ORA or for identifying new types of biomechanical properties of the cornea.
本文首次提出,在空气脉冲眼压计(ORA)测量中,当角膜在压平后进一步变深时,会出现角膜隆起。从原始数据中对气压曲线进行精确的数值分析,在曲线的明显局部干扰处,几乎正好出现在第一次和第二次压平时。在六只眼睛上进行了 30 次测量,显示出两次压平时间以及局部压力波干扰出现在气压曲线上的时间之间,以及压力波干扰幅度与相应压平曲线高度之间存在明显的相关性。这些发现可以解释为角膜隆起非常迅速,产生气压波,从角膜向仪器传播。本研究中测量和描述的定量相关性,能够对各个压平过程中的隆起进行特征描述。由于这些个体特征和相关性,可以更好地理解和描述超快的角膜压平过程。这些现象可能有助于提高 ORA 测量参数的准确性,或用于识别角膜的新型生物力学特性。