Kagan E, Jacobson R J, Yeung K Y, Haidak D J, Nachnani G H
Am J Med. 1979 Aug;67(2):325-30. doi: 10.1016/0002-9343(79)90408-x.
Three different neoplasms of B cell lineage, chronic lymphocytic leukemia, immunoglobulin A (IgA) myeloma and immunoglobulin G (IgG) myeloma were detected in three patients who had heavy occupational exposure to asbestos dust. Two of the patients had coexistent pulmonary asbestosis, whereas the third patient had a pleural mesothelioma subsequent to his initial presentation with myeloma. Defective cell-mediated immunity and hyperactivity of B cell function have previously been noted in patients with asbestosis. We suggest the possibility that these asbestos-related immunologic derangements may predispose to the development of immunoproliferative and lymphoproliferative neoplasms, since such tumors have been observed in a variety of other settings, characterized by protracted hyperactivity of the immune system.
在三名职业性大量接触石棉粉尘的患者中，检测出三种不同的B细胞系肿瘤，即慢性淋巴细胞白血病、免疫球蛋白A（IgA）骨髓瘤和免疫球蛋白G（IgG）骨髓瘤。其中两名患者同时患有肺石棉沉着病，而第三名患者在最初诊断为骨髓瘤后发生了胸膜间皮瘤。先前已注意到石棉沉着病患者存在细胞介导免疫缺陷和B细胞功能亢进。我们认为，这些与石棉相关的免疫紊乱可能易导致免疫增殖性和淋巴增殖性肿瘤的发生，因为在其他各种以免疫系统长期亢进为特征的情况下也观察到了此类肿瘤。
