Department of Research, The Cooper Institute, Dallas, Texas, USA.
Department of Medicine, Stanford University, Stanford, California, USA.
J Investig Med. 2019 Oct;67(7):1087-1090. doi: 10.1136/jim-2019-001071. Epub 2019 Jul 31.
We examined the associations among cardiorespiratory fitness (CRF), adiposity, and serum 25-hydroxyvitamin D [25(OH)D) levels in African-American (AA) adults. 468 AA patients from the Cooper Clinic in Dallas, TX were examined between 2007 and 2018. Measures included body mass index (BMI), waist circumference (WC), percent body fat (%fat) via skinfolds, CRF via a maximal treadmill test, and 25(OH)D. Participants were classified by CRF based on age and sex, as well as by clinical categories of adiposity exposures and 25(OH)D. We examined trends of 25(OH)D across CRF and adiposity categories. We calculated OR with 95% CIs for 25(OH)D deficiency across categories of CRF and adiposity measures. We observed a significant positive trend for CRF (p=0.01) and a significant inverse trend for BMI (p=0.005) across ordered 25(OH)D categories. Adjusted mean 25(OH)D levels were higher across ordered CRF categories (p=0.03), and lower across ordered categories of BMI (p=0.02), WC (p=0.03) and %fat (p=0.04). When grouped into categories of fit and unfit (upper 80% and lower 20% of the CRF distribution, respectively), OR for vitamin D deficiency was significantly lower in fit compared with unfit men and women (OR=0.55, 95% CI: 0.35-0.87, p=0.01). Compared with normal weight BMI (referent), ORs for 25(OH)D deficiency were significantly higher for BMI-obese subjects (OR=1.70, 95% CI: 1.00-2.87, p=0.04). 25(OH)D levels are positively associated with CRF and negatively associated with different measures of adiposity in AA men and women. Because of the study design, causal inferences cannot be made and future prospective studies are needed.
我们研究了心肺适能（CRF）、肥胖和血清 25-羟维生素 D [25（OH）D]水平在非裔美国人（AA）成年人中的关联。2007 年至 2018 年期间，来自德克萨斯州达拉斯库珀诊所的 468 名 AA 患者接受了检查。测量包括体重指数（BMI）、腰围（WC）、皮褶百分比体脂（%fat）、最大跑步机测试的 CRF 以及 25（OH）D。参与者根据年龄和性别以及肥胖暴露和 25（OH）D 的临床分类，按 CRF 进行分类。我们检查了 25（OH）D 在 CRF 和肥胖类别中的趋势。我们计算了 25（OH）D 在 CRF 和肥胖测量类别中缺乏的优势比（OR）及其 95%置信区间（CI）。我们观察到 CRF 呈显著正趋势（p=0.01），25（OH）D 呈显著负趋势（p=0.005）。调整后的平均 25（OH）D 水平在有序的 CRF 类别中较高（p=0.03），而在 BMI（p=0.02）、WC（p=0.03）和%fat（p=0.04）的有序类别中较低。当按健康和不健康（分别为 CRF 分布的上 80%和下 20%）分组时，健康男性和女性的维生素 D 缺乏症的 OR 明显低于不健康男性和女性（OR=0.55，95%CI：0.35-0.87，p=0.01）。与 BMI 正常的体重（参照）相比，BMI 肥胖者的 25（OH）D 缺乏症的 OR 显著更高（OR=1.70，95%CI：1.00-2.87，p=0.04）。25（OH）D 水平与 AA 男性和女性的 CRF 呈正相关，与不同的肥胖指标呈负相关。由于研究设计，不能做出因果推论，需要未来进行前瞻性研究。
