The Cooper Institute, Dallas, TX 75230, USA.
J Womens Health (Larchmt). 2012 Jan;21(1):80-6. doi: 10.1089/jwh.2010.2684. Epub 2011 Oct 4.
We examined the cross-sectional associations among cardiorespiratory fitness (CRF), different measures of adiposity, and serum vitamin D levels in women.
Between 2007 and 2010, 1320 women completed a health examination. Measures included body mass index (BMI), waist circumference (WC), waist/hip ratio, percent body fat, CRF based on a maximal treadmill exercise test, and measurement of serum vitamin D. Participants were classified by CRF as unfit (lowest 20%) and fit (remaining 80%) based on age, as well as by clinical cutoff points for adiposity measures, and by categories of serum vitamin D. We examined trends of CRF and adiposity exposures across serum vitamin D categories. We calculated odds ratios (OR) of serum vitamin D insufficiency or deficiency across levels of adiposity exposures before and after adjustment for CRF.
We observed a significant positive trend for CRF across incremental serum vitamin D categories (p<0.001). When compared to ORs for normal weight women, ORs for serum vitamin D insufficiency or deficiency were significantly higher for overweight women within each adiposity exposure (p<0.05). When grouped into categories of fit and unfit (upper 80% and lower 20% of CRF distribution, respectively), serum vitamin D was significantly lower in unfit than in fit women within each stratum of WC and waist/hip ratio and within the normal weight BMI stratum.
Serum vitamin D levels are positively associated with CRF and negatively associated with different measures of adiposity in women. Higher CRF attenuates the relationship between adiposity level and serum vitamin D. Future prospective studies are warranted.
我们研究了女性心肺适能（CRF）、不同肥胖指标与血清维生素 D 水平之间的横断面关联。
在 2007 年至 2010 年期间，1320 名女性完成了健康检查。测量指标包括体重指数（BMI）、腰围（WC）、腰臀比、体脂肪百分比、基于最大跑步机运动测试的 CRF 以及血清维生素 D 测量。根据年龄，将参与者分为 CRF 不达标（最低 20%）和达标（其余 80%）两组，也根据肥胖指标的临床临界点以及血清维生素 D 的类别进行分类。我们研究了 CRF 和肥胖暴露在不同血清维生素 D 类别中的趋势。我们在调整 CRF 后，计算了血清维生素 D 不足或缺乏的几率比（OR）在肥胖暴露水平上的变化。
我们观察到，随着血清维生素 D 类别的递增，CRF 呈现出显著的正趋势（p<0.001）。与正常体重女性相比，在每个肥胖暴露水平中，血清维生素 D 不足或缺乏的 OR 对于超重女性均显著更高（p<0.05）。当分为健康和不健康两组（分别为 CRF 分布的前 80%和后 20%）时，在每个 WC 和腰臀比分层以及正常体重 BMI 分层中，不健康组的血清维生素 D 水平显著低于健康组。
血清维生素 D 水平与 CRF 呈正相关，与女性不同的肥胖指标呈负相关。较高的 CRF 减弱了肥胖水平与血清维生素 D 之间的关系。未来需要进行前瞻性研究。
