免疫球蛋白在儿童重症肺炎治疗过程中的注射应用。
Injection of immunoglobulin in the treatment process of children with severe pneumonia.
作者信息
Chen Liping, Qi Xuehai, Li Ruiying, Wang Xudong, Shi Baohai, Meng Qingmei
机构信息
Liping Chen, Department of Pediatrics, Tai'an City Central Hospital, Tai'an, 271000, China.
Xuehai Qi, Department of Pediatrics, Tai'an Maternal and Child Health Hospital, Tai'an, 271000, China.
出版信息
Pak J Med Sci. 2019 Jul-Aug;35(4):940-944. doi: 10.12669/pjms.35.4.83.
OBJECTIVE
To observe the effect of intravenous infusion of immune globulin in the treatment of children with severe pneumonia.
METHODS
Ninety-eight children with severe pneumonia who received treatment in our hospital between April 2015 and December 2016 were selected, and they were grouped into a control group and an treatment group, 49 each group. The control group received conventional treatment. The treatment group was additionally treated with immune globulin on the basis of conventional treatment. The humoral immune indicators were detected using immunoturbidimetric assay, and the inflammatory reaction indicators were detected using enzyme-linked immunoabsorbent kit. The overall efficacy, clinical symptoms, humoral immunity and inflammatory response were compared between the two groups.
RESULTS
The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The cough, rale and fever of the treatment group disappeared faster than those of the control group, the relief of cardiac failure was also faster in the treatment group (P<0.05). The immunoglobulin G (Ig G), Ig A and Ig M of patients in the two groups compared before treatment, and no significant difference was found (P>0.05). The Ig G level of the treatment group was higher than that of the control group after treatment (P<0.05). The comparison of Ig A and Ig M between the two groups indicated no significant difference (P>0.05). The two groups had no significant differences in the content of tumor necrosis factor (TNF)-α, C-reactive protein (CRP), soluble intercellular adhesion molecule (SICAM)-1 and interferon (IFN)-γ (P>0.05) before treatment, but the content of the treatment group was significantly higher than that of the control group (P<0.01).
CONCLUSION
Immunoglobulin was significantly effective in the adjuvant treatment of children with severe pneumonia, and it can rapidly improve the improvement of symptoms, enhance immune function and inhibit inflammatory reaction; therefore it is worth promotion.
目的
观察静脉输注免疫球蛋白治疗儿童重症肺炎的效果。
方法
选取2015年4月至2016年12月在我院接受治疗的98例重症肺炎患儿，分为对照组和治疗组，每组49例。对照组采用常规治疗。治疗组在常规治疗基础上额外给予免疫球蛋白治疗。采用免疫比浊法检测体液免疫指标，使用酶联免疫吸附试剂盒检测炎症反应指标。比较两组的总体疗效、临床症状、体液免疫和炎症反应。
结果
治疗组总有效率显著高于对照组（P<0.05）。治疗组咳嗽、啰音及发热消失速度比对照组快，治疗组心力衰竭缓解也更快（P<0.05）。两组患者治疗前免疫球蛋白G（IgG）、IgA和IgM比较，差异无统计学意义（P>0.05）。治疗后治疗组IgG水平高于对照组（P<0.05）。两组IgA和IgM比较，差异无统计学意义（P>0.05）。两组治疗前肿瘤坏死因子（TNF）-α、C反应蛋白（CRP）、可溶性细胞间黏附分子（SICAM）-1和干扰素（IFN）-γ含量比较，差异无统计学意义（P>0.05），但治疗组含量显著高于对照组（P<0.01）。
结论
免疫球蛋白辅助治疗儿童重症肺炎效果显著，能迅速改善症状，增强免疫功能并抑制炎症反应；因此值得推广。
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