Li Min, Wang Jing, Wang Xinhong, Li Guojie
Department of Neurology, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China.
Department of Oncology, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China.
Exp Ther Med. 2020 Feb;19(2):939-944. doi: 10.3892/etm.2019.8275. Epub 2019 Dec 4.
Clinical efficacy of aspirin combined with clopidogrel in treating cerebral infarction and its influence on serum high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and tumor necrosis factor-α (TNF-α) were explored. Ninety patients with acute cerebral infarction treated in Yidu Central Hospital of Weifang were analyzed, and those treated with aspirin alone were group A (n=40) and those treated with aspirin and clopidogrel were group B (n=50) according to the different treatment plans. The NIHSS score, total effective rate and incidence rate of adverse reactions after treatment and admission were compared between the two groups. The expression level of hs-CRP was detected by enzyme-linked immunosorbent assay, and the expression levels of sICAM-1 and TNF-α were analyzed by radioimmunoassay before treatment and three weeks after surgery, respectively, and they were analyzed and compared. After treatment, the total effective rate of patients in group B was significantly higher than that of group A (P<0.05). The general clinical baseline information, NIHSS score, and the expression levels of hs-CRP, sICAM-1, and TNF-α of patients in group B were significantly improved after treatment compared with those before treatment (P<0.05), and the NIHSS score and the expression levels of serum hs-CRP, sICAM-1, and TNF-α of those in group B were significantly lower than those in group A (P<0.05). Combination therapy of aspirin and clopidogrel can improve cerebral infarction effectively, and inhibit the expression levels of hs-CRP, sICAM-1 and TNF-α more effectively than aspirin alone.
探讨阿司匹林联合氯吡格雷治疗脑梗死的临床疗效及其对血清高敏C反应蛋白（hs-CRP）、可溶性细胞间黏附分子-1（sICAM-1）和肿瘤坏死因子-α（TNF-α）的影响。分析在潍坊市益都中心医院接受治疗的90例急性脑梗死患者，根据不同治疗方案，将单纯使用阿司匹林治疗的患者设为A组（n = 40），将使用阿司匹林和氯吡格雷治疗的患者设为B组（n = 50）。比较两组治疗后及入院时的美国国立卫生研究院卒中量表（NIHSS）评分、总有效率及不良反应发生率。采用酶联免疫吸附测定法检测hs-CRP的表达水平，分别于治疗前及术后3周采用放射免疫测定法分析sICAM-1和TNF-α的表达水平，并进行分析比较。治疗后，B组患者的总有效率显著高于A组（P < 0.05）。B组患者治疗后的一般临床基线资料、NIHSS评分以及hs-CRP、sICAM-1和TNF-α的表达水平与治疗前相比均有显著改善（P < 0.05），且B组患者的NIHSS评分以及血清hs-CRP、sICAM-1和TNF-α的表达水平均显著低于A组（P < 0.05）。阿司匹林联合氯吡格雷治疗能有效改善脑梗死，且比单用阿司匹林更有效地抑制hs-CRP、sICAM-1和TNF-α的表达水平。
