伴有胞质嗜天青颗粒的多发性骨髓瘤

Multiple Myeloma with Intracytoplasmic Azurophilic Granules.

作者信息

Sadeghi Alireza, Nematollahi Pardis, Moghaddas Azadeh, Darakhshandeh Ali

机构信息

Department of Medical Oncology and Hematology, Isfahan University of Medical Sciences, Isfahan, Iran.

Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Int J Hematol Oncol Stem Cell Res. 2019 Apr 1;13(2):58-60.

PMID:31372198

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6660474/

Abstract

Bone marrow examination plays an important role in the diagnosis of multiple myeloma. In some cases with multiple myeloma, marrow plasma cells with cytoplasmic inclusions are seen. In this study, a 46-year- old man was evaluated for multiple myeloma. In bone marrow aspiration, large intracytoplasmic azurophilic granules, resembling intracellular microorganisms were seen. IHC study demonstrated that these cells are CD138 positive. This is a rare histologic finding that usually results from the deposition of excess immunoglobulin.

摘要

骨髓检查在多发性骨髓瘤的诊断中起着重要作用。在一些多发性骨髓瘤病例中，可见到有细胞质内含物的骨髓浆细胞。在本研究中，一名46岁男性接受了多发性骨髓瘤评估。在骨髓穿刺中，可见到胞质内有大的嗜天青颗粒，类似细胞内微生物。免疫组化研究表明这些细胞CD138呈阳性。这是一种罕见的组织学表现，通常是由于过量免疫球蛋白沉积所致。