Wang Ben, Chen Lijie, Huang Chongan, Lin Jialiang, Pan Xiangxiang, Shao Zhenxuan, Hu Sunli, Zhang Xiaolei, Wang Xiangyang
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325027, Zhejiang, China.
J Bone Oncol. 2019 Jul 9;17:100251. doi: 10.1016/j.jbo.2019.100251. eCollection 2019 Aug.
To analyse the homogeneous and heterogeneous risk factors for occurrence and prognosis in lung cancer patients diagnosed with bone metastasis (BM) by using the Surveillance, Epidemiology, and End Results (SEER) database.
The medical records of lung cancer patients with or without bone metastasis were identified in the SEER database between 2010 and 2015. A multivariate logistic regression analysis was performed to identify risk factors, and a multivariate Cox regression was used to determine the prognostic effects of every variable on survival.
In total, 34,585 eligible patients from the SEER database were included in the analysis. Male gender and metastasis to the liver were factors that were both positively associated with a risk for the development and prognosis of bone metastasis in patients with lung cancer. Younger age, poor tumour differentiation grade, higher N stage (N3), adenocarcinoma and metastasis to the brain were all positively correlated with a risk of occurrence of BM, but these factors were not correlated with an unfavourable prognosis. Age, race, marital status, tumour size and pathologic type were independent risk factors for the prognosis of bone metastasis.
The morbidity of bone metastasis in lung cancer patients is dismal, with a rate of 25.9%. The findings of this study estimate the homogeneous and heterogeneous risk factors for the occurrence and prognosis of bone metastasis in lung cancer patients, which may provide clinical guidelines for physicians.
利用监测、流行病学和最终结果（SEER）数据库分析诊断为骨转移（BM）的肺癌患者发生和预后的同质和异质风险因素。
在SEER数据库中识别2010年至2015年间有或无骨转移的肺癌患者的病历。进行多因素逻辑回归分析以识别风险因素，并使用多因素Cox回归确定每个变量对生存的预后影响。
总共34585名符合条件的患者纳入了SEER数据库分析。男性和肝转移是与肺癌患者骨转移发生和预后风险均呈正相关的因素。年龄较小、肿瘤分化程度差、N分期较高（N3）、腺癌和脑转移均与BM发生风险呈正相关，但这些因素与不良预后无关。年龄、种族、婚姻状况、肿瘤大小和病理类型是骨转移预后的独立风险因素。
肺癌患者骨转移的发病率令人沮丧，为25.9%。本研究结果估计了肺癌患者骨转移发生和预后的同质和异质风险因素，可为医生提供临床指导。
