神经疾病中的前额叶皮质。
Medial prefrontal cortex in neurological diseases.
机构信息
Department of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia.
Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan China.
出版信息
Physiol Genomics. 2019 Sep 1;51(9):432-442. doi: 10.1152/physiolgenomics.00006.2019. Epub 2019 Aug 2.
Abstract
The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.
摘要
内侧前额叶皮质（mPFC）是一个关键的皮质区域，它整合了来自众多皮质和皮质下区域的信息，并将更新的信息汇聚到输出结构中。它在认知过程、情绪调节、动机和社交能力中起着至关重要的作用。mPFC 的功能障碍已在各种神经和精神疾病中被发现，如抑郁症、焦虑障碍、精神分裂症、自闭症谱系障碍、阿尔茨海默病、帕金森病和成瘾。在本综述中，我们总结了临床前和临床研究，以说明 mPFC 在这些神经疾病中的作用。
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