PIRD：全免疫受体数据库。

PIRD: Pan Immune Repertoire Database.

机构信息

BGI-Shenzhen, Shenzhen 518083, China.

China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China.

出版信息

Bioinformatics. 2020 Feb 1;36(3):897-903. doi: 10.1093/bioinformatics/btz614.

DOI:10.1093/bioinformatics/btz614

PMID:31373607

Abstract

MOTIVATION

T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database.

RESULTS

We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualization and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD.

AVAILABILITY AND IMPLEMENTATION

PIRD can be freely accessed at https://db.cngb.org/pird.

摘要

动机

T 细胞受体 (TCRs) 和 B 细胞受体 (BCRs) 通过识别大量的外部和内部抗原，在适应性免疫系统中发挥着关键作用。了解这些受体对于探索免疫反应过程以及利用免疫疗法和抗体药物设计中的潜在应用至关重要。尽管近年来已经使用高通量测序对大量样本的 TCR 和 BCR 进行了测序，但构建存储这些数据的数据库却很少。为了解决这个问题，我们开发了一个数据库。

结果

我们开发了一个数据库，即泛免疫受体数据库（PIRD），位于中国国家基因库（CNGBdb）中，用于收集和存储注释的 TCR 和 BCR 测序数据，包括来自人类和其他物种的数据。除了数据存储，PIRD 还提供了数据可视化和交互式在线分析的功能。此外，一个针对已知抗原的 TCRs 和 BCRs 的手动整理数据库 (TBAdb) 也被存入了 PIRD。