视网膜和耳蜗中的带状突触的感觉处理。

Sensory Processing at Ribbon Synapses in the Retina and the Cochlea.

机构信息

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany; Synaptic Nanophysiology Group, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany; and Institute for Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, Homburg, Germany.

出版信息

Physiol Rev. 2020 Jan 1;100(1):103-144. doi: 10.1152/physrev.00026.2018. Epub 2019 Aug 2.

DOI:10.1152/physrev.00026.2018

PMID:31373863

Abstract

In recent years, sensory neuroscientists have made major efforts to dissect the structure and function of ribbon synapses which process sensory information in the eye and ear. This review aims to summarize our current understanding of two key aspects of ribbon synapses: ) their mechanisms of exocytosis and endocytosis and ) their molecular anatomy and physiology. Our comparison of ribbon synapses in the cochlea and the retina reveals convergent signaling mechanisms, as well as divergent strategies in different sensory systems.

摘要

近年来，感觉神经科学家在努力剖析在眼和耳中处理感觉信息的带状突触的结构和功能。这一综述旨在总结我们当前对带状突触两个关键方面的理解：(1)它们的胞吐和胞吞机制；(2)它们的分子解剖和生理学。我们对耳蜗和视网膜中带状突触的比较揭示了趋同的信号转导机制，以及不同感觉系统中不同的策略。