Tripathy N K, Majhi B, Dey L, Patnaik K, Das C C
Department of Zoology, Berhampur University, India.
Mutat Res. 1987 Nov;189(3):277-83. doi: 10.1016/0165-1218(87)90059-0.
The genotoxicity of dimecron, a systemic organophosphate pesticide, has been tested in the wing, eye and germ line mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. Larvae heterozygous for recessive marker mutations were fed the compound for various periods of time. On emergence, the wings and eyes of the adults were screened for mosaic spots and the eggs laid by the females were checked for induction of female germ line mosaicism. Dimecron is mutagenic to the somatic and germ line cells of Drosophila and induces a high frequency of sex-linked recessive lethals.
乐果是一种有机磷内吸性杀虫剂，其遗传毒性已在黑腹果蝇的翅、眼和生殖系嵌合体试验以及性连锁隐性致死试验中进行了测试。将携带隐性标记突变的杂合子幼虫喂食该化合物不同时间段。成虫羽化后，检查其翅膀和眼睛是否有镶嵌斑点，并检查雌性果蝇所产的卵，以检测雌性生殖系嵌合体的诱导情况。乐果对果蝇的体细胞和生殖系细胞具有致突变性，并诱导产生高频率的性连锁隐性致死突变。
