Zonnino Andrea, Smith Daniel R, Delgorio Peyton L, Johnson Curtis L, Sergi Fabrizio
IEEE Int Conf Rehabil Robot. 2019 Jun;2019:270-275. doi: 10.1109/ICORR.2019.8779562.
Non-invasive in-vivo measurement of individual muscle force is limited by the infeasibility of placing force sensing elements in series with the musculo-tendon structures. While different methods based either on shear wave elastography or electromyography have been recently proposed to non-invasively estimate individual muscle forces, they can only be used to quantity forces in a limited set of superficial muscles. As such, they are not suitable to study the neuromuscular control of movements that require coordinated action of multiple muscles. In this work, we present multi-muscle magnetic resonance elastography (MM-MRE), a new technique capable of quantifying force for each muscle in the forearm, thus enabling the study of the neuromuscular control of wrist movements. To quantity individual muscle force, MM-MRE integrates measurements of joint torque provided by an MRI-compatible instrumented handle with muscle-specific measurements of shear wave speed obtained via MRE into a forward dynamic muscle force estimator based on a realistic musculoskeletal model of the forearm. A single-subject pilot experiment demonstrates the possibility of obtaining measurements from individual muscles and establishes that MM-MRE has sufficient sensitivity to detect changes in the muscle specific measurement of shear-wave speed following the application of isometric flexion and extension torques with self-selected intensity.
由于无法将力传感元件与肌腱结构串联放置，个体肌肉力量的非侵入性体内测量受到限制。虽然最近有人提出了基于剪切波弹性成像或肌电图的不同方法来非侵入性地估计个体肌肉力量，但它们只能用于测量有限的一组浅表肌肉中的力量。因此，它们不适用于研究需要多块肌肉协同作用的运动的神经肌肉控制。在这项工作中，我们提出了多肌肉磁共振弹性成像（MM-MRE），这是一种能够量化前臂各块肌肉力量的新技术，从而能够研究手腕运动的神经肌肉控制。为了量化个体肌肉力量，MM-MRE将由磁共振成像兼容的仪器化手柄提供的关节扭矩测量值与通过磁共振弹性成像获得的特定肌肉剪切波速度测量值整合到基于前臂真实肌肉骨骼模型的正向动态肌肉力量估计器中。一项单受试者初步实验证明了从个体肌肉获取测量值的可能性，并确定MM-MRE具有足够的灵敏度来检测在以自选强度施加等长屈伸扭矩后肌肉特定剪切波速度测量值的变化。
