Yushchenko Maksym, Sarracanie Mathieu, Salameh Najat
Center for Adaptable MRI Technology (AMT Center), Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland.
Sci Adv. 2022 Sep 9;8(36):eabo5739. doi: 10.1126/sciadv.abo5739.
Most commonly used at clinical magnetic fields (1.5 to 3 T), magnetic resonance elastography (MRE) captures mechanical wave propagation to reconstruct the mechanical properties of soft tissue with MRI. However, in terms of noninvasively assessing disease progression in a broad range of organs (e.g., liver, breast, skeletal muscle, and brain), its accessibility is limited and its robustness is challenged when magnetic susceptibility differences are encountered. Low-field MRE offers an opportunity to overcome these issues, and yet it has never been demonstrated in vivo in humans with magnetic fields <1.5 T mainly because of the long acquisition times required to achieve a sufficient signal-to-noise ratio. Here, we describe a method to accelerate 3D motion-sensitized MR scans at 0.1 T using only 10% -space sampling combined with a high-performance detector and an efficient encoding acquisition strategy. Its application is demonstrated in vivo in the human forearm for a single motion-encoding direction in less than 1 min.
磁共振弹性成像（MRE）最常用于临床磁场（1.5至3 T），它通过捕捉机械波传播，利用磁共振成像（MRI）重建软组织的力学特性。然而，在无创评估多种器官（如肝脏、乳腺、骨骼肌和大脑）的疾病进展方面，当遇到磁化率差异时，其可及性有限且稳健性受到挑战。低场MRE为克服这些问题提供了契机，但由于在磁场<1.5 T的人体中进行体内实验时，为获得足够的信噪比需要很长的采集时间，所以此前从未在人体中得到证实。在此，我们描述了一种方法，仅使用10%的空间采样，结合高性能探测器和高效编码采集策略，在0.1 T下加速三维运动敏感磁共振扫描。该方法在人体前臂针对单一运动编码方向进行了体内实验演示，扫描时间不到1分钟。
