Systems Biology Program, Graduate School of Media and Governance, Keio University, Kanagawa 252-0882, Japan.
Health Science Laboratory, Keio Research Institute at SFC, Kanagawa 252-0882, Japan.
Nutrients. 2019 Aug 1;11(8):1779. doi: 10.3390/nu11081779.
A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin by administering it to a mouse model of diet-induced NASH. Melon GliSODin suppressed liver fibrosis and fat accumulation, which is characteristic of the NASH phenotype. Gene expression analysis confirmed the suppression of fat synthesis and activation of antioxidative mechanisms. These results show that Melon GliSODin mitigates NASH onset at the molecular level, suggesting its potential application as a NASH preventive agent.
高热量饮食会导致肝脏脂肪堆积和氧化应激，从而导致脂肪肝，最终发展为非酒精性脂肪性肝炎（NASH）。由于具有抗氧化活性，瓜氨酸GliSODin 被用作营养补充剂。本研究旨在评估瓜氨酸 GliSODin 的抗氧化活性及其预防 NASH 的效果，NASH 主要是由氧化应激引起的。此外，我们通过给予饮食诱导的 NASH 小鼠模型验证了瓜氨酸 GliSODin 的保护作用。瓜氨酸 GliSODin 抑制了 NASH 表型的特征性肝纤维化和脂肪堆积。基因表达分析证实了脂肪合成的抑制和抗氧化机制的激活。这些结果表明，瓜氨酸 GliSODin 从分子水平上减轻了 NASH 的发生，提示其作为 NASH 预防剂的潜在应用。
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