School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Mini Rev Med Chem. 2024;24(21):1894-1929. doi: 10.2174/0113895575306598240503054317.
Nonalcoholic steatohepatitis (NASH), a multi-target disease, is becoming a global epidemic. Although several anti-NASH drug candidates are being evaluated in late-stage clinical trials, none have been approved by the FDA to date. Given the global prevalence of the disease, the lack of effective drugs, and the very limited therapeutic efficacy of most of the existing synthetic drugs focusing on a single target, there is an urgent need to continue to develop new therapeutic agents. In contrast, many natural products, including pure compounds and crude extracts, possess hepatoprotective activities. Usually, these natural components are characterized by multi-targeting and low side effects. Therefore, natural products are important resources for the development of new anti- NASH drugs. In this paper, we focus on reviewing the anti-NASH potential, structure, and some of the side effects of natural products based on structural classification. We hope this mini-review will help researchers design and develop new anti-NASH drugs, especially based on the structure of natural products.
非酒精性脂肪性肝炎（NASH）是一种多靶点疾病，正在成为全球性的流行疾病。尽管有几种抗 NASH 药物候选物正在进行后期临床试验，但迄今为止尚未有任何一种被 FDA 批准。鉴于该疾病的全球流行率、缺乏有效药物以及大多数针对单一靶点的现有合成药物的治疗效果非常有限，因此迫切需要继续开发新的治疗药物。相比之下，许多天然产物，包括纯化合物和粗提取物，具有保肝活性。通常，这些天然成分的特点是多靶点和低副作用。因此，天然产物是开发新型抗 NASH 药物的重要资源。在本文中，我们重点根据结构分类综述了天然产物的抗 NASH 潜力、结构和一些副作用。我们希望这篇简短的综述能帮助研究人员设计和开发新型抗 NASH 药物，特别是基于天然产物的结构。
