非快速眼动睡眠期异态睡眠：精准医学的前景

Non-REM Parasomnia: The Promise of Precision Medicine.

作者信息

Erickson Joel, Vaughn Bradley V

机构信息

Department of Neurology, University of North Carolina, Chapel Hill, University of North Carolina School of Medicine, CB#7025, Chapel Hill, NC 27599-7025, USA.

出版信息

Sleep Med Clin. 2019 Sep;14(3):363-370. doi: 10.1016/j.jsmc.2019.05.002. Epub 2019 Jul 1.

DOI:10.1016/j.jsmc.2019.05.002

PMID:31375204

Abstract

Our understanding of non-REM parasomnias is just beginning to unfold the potential biomarkers and underlying pathophysiologic processes that lead to these events. Biomarkers need further investigation and will help us to understand better ways to develop risk models and possible mechanisms. Similarly, as we develop more accurate pathophysiologic-based diagnostic testing for non-REM parasomnias, we will begin the evolution toward a physiologic-based classification scheme that aids the application of precision medicine. This article explores currently known characteristics and exploratory features that may aid in this transition to better understanding our individual patients with non-REM parasomnias and tailoring their treatments.

摘要

我们对非快速眼动期睡眠障碍的理解才刚刚开始揭示导致这些事件的潜在生物标志物和潜在病理生理过程。生物标志物需要进一步研究，这将帮助我们更好地理解开发风险模型的方法和可能的机制。同样，随着我们为非快速眼动期睡眠障碍开发更准确的基于病理生理学的诊断测试，我们将开始朝着基于生理学的分类方案发展，这有助于精准医学的应用。本文探讨了目前已知的特征和探索性特征，这些特征可能有助于实现这一转变，从而更好地了解患有非快速眼动期睡眠障碍的个体患者并为其量身定制治疗方案。