Carter Patricia, Ye Lichuan, Richards Kathy, Vallabhaneni Vani
School of Nursing, University of Texas at Austin, 1710 Red River Street, Austin, TX 78712, USA.
School of Nursing, Bouve College of Health Sciences, Northeastern University, 207c Robinson Hall, 360 Huntington Avenue, Boston, MA 02115, USA.
Sleep Med Clin. 2019 Sep;14(3):371-378. doi: 10.1016/j.jsmc.2019.05.001. Epub 2019 Jun 8.
Given the complex and bidirectional nature of sleep and mild cognitive impairment/Alzheimer's disease and related dementias, a precision medicine approach to education, lifestyle changes, and early assessment in patients with a family history of snoring, sleep apnea, diabetes, and heart disease is warranted. Furthermore, a team-based approach allows for a coordinated precision diagnosis and management of common comorbid chronic illnesses. The significance of sleep disturbances in this population, contributing factors, assessment and diagnostic challenges, common sleep disorders and mechanisms, tailored behavioral and pharmacologic interventions, knowledge gaps, and future research ideas are discussed.
鉴于睡眠与轻度认知障碍/阿尔茨海默病及相关痴呆症之间复杂的双向关系，对于有打鼾、睡眠呼吸暂停、糖尿病和心脏病家族史的患者，采用精准医学方法进行教育、改变生活方式以及早期评估是必要的。此外，基于团队的方法能够对常见的慢性合并症进行协调的精准诊断和管理。本文讨论了该人群睡眠障碍的重要性、促成因素、评估和诊断挑战、常见睡眠障碍及机制、针对性的行为和药物干预、知识空白以及未来的研究思路。
