Department of Clinical and Experimental Sciences, University of Brescia, Piazzale Spedali Civili, 1, 25100, Brescia, Italy.
Geriatric Research Group, Brescia, Italy.
Aging Clin Exp Res. 2018 Jun;30(6):661-668. doi: 10.1007/s40520-017-0814-8. Epub 2017 Aug 28.
Prior studies documented that several sleep disorders may coexist in patients affected by Mild Cognitive Impairment (MCI) and Alzheimer disease (AD), and have a strong bidirectional relationship with cognitive decline.
To assess the self-reported sleep quality and daytime sleepiness among subjects affected by MCI and AD at early-stage and healthy controls, and to verify if sleep disturbances might be an indicator of specific cognitive deficits.
139 patients (102 MCI, 37 AD) underwent comprehensive neuropsychological, functional, and behavioral assessment, which also included Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). 80 healthy elderly subjects were used as controls. MCI patients have been divided into Good Sleepers and Bad Sleepers, depending on their reported sleep quality (PSQI global score ≤5/>5).
MCI patients experienced more subjective daytime sleepiness than AD matches. As for the subjective sleep quality among MCI patients, 54% of Bad Sleepers met diagnostic criteria for non-amnestic MCI; vice-versa, 73% of Good Sleepers were diagnosed with amnestic-MCI (p = 0.005), independently of depression and anxiety.
MCI patients complain of daytime sleepiness and dysfunction more than AD patients; among MCI patients, Bad Sleepers appear mainly characterized by a non-amnestic cognitive profile.
先前的研究表明，几种睡眠障碍可能同时存在于轻度认知障碍（MCI）和阿尔茨海默病（AD）患者中，并且与认知能力下降有很强的双向关系。
评估早期 MCI 和 AD 患者以及健康对照组的自我报告睡眠质量和白天嗜睡情况，并验证睡眠障碍是否可能是特定认知缺陷的指标。
139 名患者（102 名 MCI，37 名 AD）接受了全面的神经心理学、功能和行为评估，其中还包括 Epworth 嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI）。80 名健康老年人作为对照组。MCI 患者根据他们报告的睡眠质量（PSQI 总分≤5/>5）分为良好睡眠者和不良睡眠者。
MCI 患者比 AD 患者经历更多的主观白天嗜睡。对于 MCI 患者的主观睡眠质量，54%的不良睡眠者符合非遗忘性 MCI 的诊断标准；相反，73%的良好睡眠者被诊断为遗忘性 MCI（p=0.005），与抑郁和焦虑无关。
MCI 患者比 AD 患者抱怨更多的白天嗜睡和功能障碍；在 MCI 患者中，不良睡眠者主要表现为非遗忘性认知特征。
