阻塞性睡眠呼吸暂停P4治疗方法的进一步发展

Further Development of P4 Approach to Obstructive Sleep Apnea.

作者信息

Pack Allan I

机构信息

Translational Research Laboratories, Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Suite 2100, 125 South 31st Street, Philadelphia, PA 19104-3403, USA.

出版信息

Sleep Med Clin. 2019 Sep;14(3):379-389. doi: 10.1016/j.jsmc.2019.05.004. Epub 2019 Jul 4.

DOI:10.1016/j.jsmc.2019.05.004

PMID:31375206

Abstract

Obstructive sleep apnea (OSA) is a heterogeneous disorder. Cluster analysis has identified different physiologic subtypes with respect to symptoms. A difference exists in cardiovascular risk from OSA between the 7 subtypes identified. There are 3 basic subtypes replicated in multiple studies: (a) a group where insomnia is the main symptom; (b) an asymptomatic group; (c) a group with marked excessive sleepiness. The symptomatic benefit from treatment with nasal CPAP varies between these 3 subtypes. Data from the Sleep Heart Health Study reveal that the increased risk of cardiovascular disease from OSA occurs only in the excessively sleepy group.

摘要

阻塞性睡眠呼吸暂停（OSA）是一种异质性疾病。聚类分析已识别出与症状相关的不同生理亚型。在已识别的7种亚型中，OSA导致的心血管风险存在差异。有3种基本亚型在多项研究中得到重复验证：（a）以失眠为主要症状的一组；（b）无症状组；（c）明显过度嗜睡的一组。这3种亚型使用鼻持续气道正压通气（CPAP）治疗后的症状改善情况各不相同。睡眠心脏健康研究的数据显示，OSA导致的心血管疾病风险增加仅发生在过度嗜睡组。