Respiratory Diseases, University of Bari, Italy.
Respiratory Diseases, University of Foggia, Italy.
Arch Bronconeumol (Engl Ed). 2020 Apr;56(4):214-217. doi: 10.1016/j.arbres.2019.06.016. Epub 2019 Jul 30.
Several studies have previously demonstrated that long-term exposure to outdoor pollution present airway inflammation in term of an increase of sputum neutrophils.
The aim of our study was to evaluate the level of airway inflammation by induced sputum in a group of 15 non-professionally exposed population of well-characterized COPD patients, residing in urban areas with high rate of outdoor pollution, compared to a control group of 13 individuals with COPD, living in rural areas with a low pollution rate. All participants underwent spirometry and sputum induction.
A statistically significant increase in the percentage of neutrophil cell count was found among the residents in urban areas compared to those living in rural regions (89.1 vs 79.0, p<0.05) CONCLUSIONS: In conclusion, we showed that non-professionally exposed patients with COPD residing in highly-polluted urban areas had greater airway inflammation in terms of sputum neutrophils compared to a population with very similar characteristics, living in rural areas with lower outdoor pollution. The results of this pilot study may be relevant for the long term effect of environmental outdoor pollution in vulnerable patients like those with COPD.
先前有几项研究表明，长期暴露于户外污染会导致气道炎症，表现为痰中中性粒细胞增多。
我们的研究目的是评估一组 15 名非职业暴露于高污染率城市地区的 COPD 患者与一组 13 名居住在低污染率农村地区的 COPD 患者的气道炎症程度。所有参与者均接受了肺量测定和痰诱导。
与生活在农村地区的人相比，居住在城市地区的人痰中中性粒细胞计数的百分比有统计学意义的增加（89.1%比 79.0%，p<0.05）。
总之，我们表明，与生活在污染较低的农村地区、具有非常相似特征的人群相比，居住在高污染城市地区的非职业暴露 COPD 患者的痰中性粒细胞炎症更大。这项初步研究的结果可能与环境户外污染对 COPD 等脆弱患者的长期影响有关。
