Guo Chenxia, Sun Xiaoyan, Diao Wenqi, Shen Ning, He Bei
Department of Respiratory Medicine, Peking University Third Hospital, Beijing, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2020 Jun 26;15:1507-1517. doi: 10.2147/COPD.S254129. eCollection 2020.
Short-term exposure to major air pollutants can increase the risk of acute exacerbation in chronic obstructive pulmonary disease (COPD) patients. However, evidence on the mechanism of acute exacerbation of COPD (AECOPD) caused by air pollutants is still limited. A total of 78 patients with stable COPD and 58 healthy controls were recruited in Peking University Third Hospital in China from December 2014 to January 2015. The correlation and lag effect over 7 days (lag1-7) of 6 air pollutants with clinical symptoms and inflammatory markers in induced sputum were analyzed. PM, NO and CO were positively correlated with the COPD assessment test (CAT) score at lag 5, PM was positively correlated with the CAT score at lag 3, MMP-9 and IL-8 were positively correlated with PM, PM and NO at lag 2, and CO was positively correlated with each other marker at lag 4. Short-term exposure to PM, PM, NO, and CO can cause a neutrophil-mediated airway inflammatory response, followed by increased clinical symptoms. If the PM, PM, NO and CO exposure levels increase during air pollution monitoring, the early usage of medication or reduction of exposure to pollutants can effectively reduce the clinical symptoms of patients.
短期暴露于主要空气污染物可增加慢性阻塞性肺疾病（COPD）患者急性加重的风险。然而，关于空气污染物导致COPD急性加重（AECOPD）的机制的证据仍然有限。2014年12月至2015年1月，在中国北京大学第三医院招募了78例稳定期COPD患者和58例健康对照。分析了6种空气污染物与诱导痰中的临床症状和炎症标志物在7天内（滞后1 - 7天）的相关性和滞后效应。PM、NO和CO在滞后5天时与COPD评估测试（CAT）评分呈正相关，PM在滞后3天时与CAT评分呈正相关，MMP - 9和IL - 8在滞后2天时与PM、PM和NO呈正相关，CO在滞后4天时与其他各标志物呈正相关。短期暴露于PM、PM、NO和CO可引起中性粒细胞介导的气道炎症反应，随后临床症状加重。如果在空气污染监测期间PM、PM、NO和CO暴露水平升高，早期使用药物或减少污染物暴露可有效减轻患者的临床症状。
