临床神经修复学：今日与明日。
Clinical neuroprosthetics: Today and tomorrow.
机构信息
Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA.
Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA.
出版信息
J Clin Neurosci. 2019 Oct;68:13-19. doi: 10.1016/j.jocn.2019.07.056. Epub 2019 Jul 30.
Implantable neurostimulation devices provide a direct therapeutic link to the nervous system and can be considered brain-computer interfaces (BCI). Under this definition, BCI are not simply science fiction, they are part of existing neurosurgical practice. Clinical BCI are standard of care for historically difficult to treat neurological disorders. These systems target the central and peripheral nervous system and include Vagus Nerve Stimulation, Responsive Neurostimulation, and Deep Brain Stimulation. Recent advances in clinical BCI have focused on creating "closed-loop" systems. These systems rely on biomarker feedback and promise individualized therapy with optimal stimulation delivery and minimal side effects. Success of clinical BCI has paralleled research efforts to create BCI that restore upper extremity motor and sensory function to patients. Efforts to develop closed loop motor/sensory BCI is linked to the successes of today's clinical BCI.
可植入神经刺激设备为神经系统提供了直接的治疗联系，可被视为脑机接口 (BCI)。根据这一定义，BCI 并非仅仅是科幻小说，而是现有神经外科实践的一部分。临床 BCI 是治疗历史上难以治疗的神经疾病的标准护理方法。这些系统针对中枢和外周神经系统，包括迷走神经刺激、反应性神经刺激和深部脑刺激。临床 BCI 的最新进展集中在创建“闭环”系统上。这些系统依赖于生物标志物反馈，并承诺通过最佳的刺激传递和最小的副作用实现个体化治疗。临床 BCI 的成功与为患者恢复上肢运动和感觉功能而创建 BCI 的研究工作相媲美。开发闭环运动/感觉 BCI 的努力与当今临床 BCI 的成功密切相关。
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