Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan.
Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan.
Trends Endocrinol Metab. 2019 Sep;30(9):569-571. doi: 10.1016/j.tem.2019.07.017. Epub 2019 Jul 31.
Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo. This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.
最近，Koronowski 等人（Cell，2019）表明，在其他遗传节律失常的小鼠中重建肝脏生物钟，可恢复体内烟酰胺腺嘌呤二核苷酸回收途径和糖生成的每日节律。这种肝脏自主代谢循环在持续黑暗条件下无法维持，这揭示了每日光周期对恢复肝功能的重要性。
