Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
Braz J Otorhinolaryngol. 2020 Sep-Oct;86(5):617-625. doi: 10.1016/j.bjorl.2019.04.002. Epub 2019 May 20.
Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies.
To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma.
The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n=42) and nasopharyngitis patients (n=22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined.
The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p<0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p<0.05), which was correlated with TNM staging (p<0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells.
The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma.
鼻咽癌是一种上皮来源的恶性肿瘤，由于其解剖位置和非典型的早期症状，当诊断为侵袭和转移时往往已经发生。这就需要更好地了解其发展机制，识别诊断标志物，并开发新的治疗策略。
研究 LMP1 和 Cripto-1 在鼻咽癌中的关系。
检测鼻咽癌患者（n=42）和鼻咽部炎症患者（n=22）标本中 LMP1 和 Cripto-1 的表达情况。还检测了 LMP1 阴性和 LMP1 阳性（CNE1-LMP1）细胞中 LMP1 和 Cripto-1 的表达情况。
LMP1 和 Cripto-1 的表达在鼻咽癌中明显高于鼻咽部炎症（p<0.05）。有转移的鼻咽癌中 LMP1 和 Cripto-1 的表达明显高于无转移者（p<0.05），且与 TNM 分期相关（p<0.05）。在 CNE1-LMP1 细胞中观察到 Cripto-1 表达较高和增殖率较高。
鼻咽癌中 LMP1 和 Cripto-1 的表达呈正相关。它们的共表达可能有助于鼻咽癌的增殖和转移。
