Stewart B R, Broekkamp C L
MRC Movement Disorders Group, University Department of Neurology, London, UK.
Psychopharmacology (Berl). 1988;95(2):268-70. doi: 10.1007/BF00174522.
Apomorphine-induced limb flicks in cats have been ascribed to a central dopamino-mimetic action of the drug. In these experiments we investigated the role of receptors located outside the blood-brain barrier (BBB) in the induction of limb flicking. Domperidone, a dopamine-receptor blocker which does not readily pass through the BBB, antagonised the induction of limb-flicks induced by apomorphine. This suggests that limb flicking behaviour may involve interactions with receptors located before the BBB. In contrast, 6-amino-5,6,7,8-tetrahydro-1,2-naphtalenediol HBr (6-ATN), a dopamine-agonist which does not penetrate the BBB, did not induce limb flicks, indicating that receptor stimulation outside the BBB alone is not sufficient to induce limb flicks. We suggest that limb flicks in cats is a behaviour which can be elicited by combined activation of centrally located dopamine receptors and dopamine receptors in the area postrema.
阿扑吗啡诱发的猫肢体轻弹被归因于该药物的中枢多巴胺模拟作用。在这些实验中，我们研究了位于血脑屏障（BBB）之外的受体在诱发肢体轻弹中的作用。多潘立酮是一种不易穿过血脑屏障的多巴胺受体阻滞剂，它能拮抗阿扑吗啡诱发的肢体轻弹。这表明肢体轻弹行为可能涉及与位于血脑屏障之前的受体相互作用。相比之下，6-氨基-5,6,7,8-四氢-1,2-萘二醇氢溴酸盐（6-ATN）是一种不能穿透血脑屏障的多巴胺激动剂，它不会诱发肢体轻弹，这表明仅血脑屏障之外的受体刺激不足以诱发肢体轻弹。我们认为，猫的肢体轻弹是一种可通过中枢多巴胺受体和最后区多巴胺受体的联合激活而引发的行为。
